Romeo's Medical Condition

Romeo is a miniature Australian shepherd. He has tested positive for the MDR1 mutation, which means that many common veterinary drugs are toxic (in varying dosages) to Romeo. Should Romeo need veterinary care, please make sure the vet knows this. Dr. Carrillo has it noted, but in case you need to bring Romeo to an emergency clinic, please be sure to bring this list because this is a relatively new discovery in veterinary medicine.

Here is the list of problem drugs as well:

Problem Drugs
There are many different types of drugs that have been reported to cause problems in Collies, ranging from over-the-counter antidiarrheal agents like Imodium® to antiparasitic and chemotherapy agents. It is likely this list will grow to include more drugs as our research progresses.Drugs that have been documented, or are strongly suspected to cause problems in dogs with the MDR1 mutation:
Ivermectin (antiparasitic agent)
Loperamide (Imodium®; over-the-counter antidiarrheal agent)
Doxorubicin (anticancer agent)
Vincristine (anticancer agent)
Vinblastine (anticancer agent)
Cyclosporin (immunosuppressive agent)
Digoxin (heart drug)
Acepromazine (tranquilizer)
Butorphanol (pain control)

Potential Problem Drugs
The following drugs may potentially cause problems when given to dogs that have the mutation. Biochemical studies have shown that this gene has the potential to act on over 50 different drugs.
Ondansetron
Domperidone
Paclitaxel
Mitoxantrone
Etoposide
Rifampicin
Quinidine
Morphine

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